FIZZ1 potentiates the carbachol-induced tracheal smooth muscle contraction
نویسندگان
چکیده
منابع مشابه
FIZZ1 potentiates the carbachol-induced tracheal smooth muscle contraction.
FIZZ1 is an adipokine highly expressed under inflammatory conditions, and yet, little is known of its function. In this study we examine the expression and function of FIZZ1 in an ovalbumin mouse model of asthma. Trachea from naïve or ovalbumin-sensitised and -challenged mice were compared for transcriptional, functional and proteomic differences using gene microarrays, ex vivo tracheal contrac...
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Cyclic ADP-ribose (cADPR), a universal calcium releaser, is generated from NAD(+) by an ADP-ribosyl cyclase and is degraded to ADP-ribose by a cADPR hydrolase. In mammals, both activities are expressed as ectoenzymes by the transmembrane glycoprotein CD38. CD38 was identified in both epithelial cells and smooth myocytes isolated from bovine trachea. Intact tracheal smooth myocytes (TSMs) respon...
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متن کاملpreventive effects of ipratropium and salbutamol against insulin induced tracheal smooth muscle contraction in guinea pig model
inhalational insulin was withdrawn from the market due to its potential to produce airway hyper-reactivity and bronchoconstriction. so the present study was designed to explore the acute effects of insulin on airway reactivity of guinea pigs and protective effects of salbutamol and ipratropium against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pig. ...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2010
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00097609